ECLIPSE 研究：5年随访下冷冻消融术对转移性肺肿瘤的疗效
SCI
11 September 2021
The ECLIPSE Study: Efficacy of cryoablation on metastatic lung tumors with a 5-year follow-up
（JOURNAL OF THORACIC ONCOLOGY；IF:15.609）
De Baère T, Woodrum D, Tselikas L, et al. The ECLIPSE Study: Efficacy of cryoablation on metastatic lung tumors with a 5-year follow-up. J Thorac Oncol 2021.
CORRESPONDENCE TO : [email protected]
The ECLIPSE study aimed to assess the feasibility and efficacy of cryoablation for local tumor control in patients with pulmonary metastatic disease over five years of follow-up.
ECLIPSE 研究旨在评估冷冻消融术在五年随访中对肺转移性疾病患者局部肿瘤控制的可行性和有效性。
ECLIPSE was a prospective, multicenter, single-arm study which included patients treated with cryoablation if they had 1-5 metastatic lung tumors, each with a diameter of ≤ 3.5 cm. Patients were followed up over the course of five years. The primary endpoint was local tumor control, both per tumor and per patient; secondary endpoints included cancer-specific survival, overall survival (OS), and quality of life. Quality of life was assessed using the Karnofsky Performance Score, the Eastern Cooperative Oncology Group Performance Score, and the Short Form-12 health survey.
ECLIPSE 是一项前瞻性、多中心、单臂研究，纳入了接受冷冻消融治疗的患者，若他们有 1-5 个转移性肺肿瘤且每个病灶直径≤ 3.5 cm。我们对患者进行了为期五年的随访。主要终点是每个肿瘤和每个患者的局部肿瘤控制；次要终点包括癌症特异性生存率、总生存率 (OS) 和生活质量。生活质量由Karnofsky Performance评分、Eastern Cooperative Oncology Group Performance评分和 Short Form-12 健康调查进行评估。
The study included 40 patients across 4 sites (3 US and 1 European). A total of 60 metastatic pulmonary tumors were treated with 48 cryoablation procedures. Overall local tumor control rates were 87.9% (29/33) and 79.2% (19/24) per tumor, and 83.3% (20/24) and 75.0% (15/20) per patient, at 3 and 5 years respectively. A total of 5 treated patients demonstrated local progression throughout the duration of the study. Disease specific survival rate was of 74.8% at 3 years and 55.3% at 5 years while overall survival at 3 and 5 years were of 63.2% and 46.7% respectively. Patient quality of life scores did not reach statistical significance.
该研究包括来自 4 个地点（3 个美国和 1 个欧洲）的 40 名患者。总共 60 个转移性肺肿瘤接受了 48 次冷冻消融手术。在 3 年和 5 年时，每个肿瘤的总体局部肿瘤控制率分别为 87.9% (29/33) 和 79.2% (19/24)，每个患者分别为 83.3% (20/24) 和 75.0% (15/20)。在整个研究期间，共有 5 名接受治疗的患者出现局部进展。3 年疾病特异性生存率为 74.8%，5 年为 55.3%，而 3 年和 5 年总生存率分别为 63.2% 和 46.7%。患者生活质量评分未达到统计学意义。
Cryoablation is an effective means of long-term local tumor control in patients with metastatic pulmonary tumors.
冷冻消融是转移性肺肿瘤患者长期局部肿瘤控制的有效手段。
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